Components of bee venom and medicinal properties of bee venom
A savior that goes against the image
Bee venom was the savior of mankind
Bee stings cause severe pain and swelling. "Bees are terrible insects that sting with stingers that come out of their buttocks!" This is probably the image of bees that many people have.
But did you know that the poison actually has amazing effects?
Bee venom is expected to have antibacterial, anti-inflammatory, and anti-cancer effects, including antibacterial, anti-inflammatory, and anti-cancer effects. Bee venom contains many gifts to mankind. Did you know that bee stings can cause severe pain and swelling, but in fact, their venom can do wonders?
Bee venom is expected to have antibacterial, anti-inflammatory, and anti-cancer effects, including antibacterial, anti-inflammatory, and anti-cancer effects. Bee venom can be medicine! It is necessary to know what the effect of surprise is.
But did you know that the poison actually has amazing effects?
Bee venom is expected to have antibacterial, anti-inflammatory, and anti-cancer effects, including antibacterial, anti-inflammatory, and anti-cancer effects. Bee venom contains many gifts to mankind. Did you know that bee stings can cause severe pain and swelling, but in fact, their venom can do wonders?
Bee venom is expected to have antibacterial, anti-inflammatory, and anti-cancer effects, including antibacterial, anti-inflammatory, and anti-cancer effects. Bee venom can be medicine! It is necessary to know what the effect of surprise is.
Components of bee venom
The effect of the poison of natural drop bees called melitin
Bee venom is made up of compounds such as amines, small molecular peptides, and enzymes. Among them, the ingredient that has attracted the most attention is melitin. Melitin is the main ingredient, accounting for about 50% of bee venom, and has strong physiological activity.
Melitin has the effect of destroying cells by puncturing cell membranes, and this action can kill pathogens such as bacteria and viruses.
It also activates cells in the immune system and reduces inflammation.
It has also been reported to be selectively toxic to cancer cells.
Bee venom has been used as a folk medicine since ancient times.
In particular, melitin has been verified in many studies and has reported antibacterial, anti-inflammatory, and anti-cancer effects.
Melitin has the effect of destroying cells by puncturing cell membranes, and this action can kill pathogens such as bacteria and viruses.
It also activates cells in the immune system and reduces inflammation.
It has also been reported to be selectively toxic to cancer cells.
Bee venom has been used as a folk medicine since ancient times.
In particular, melitin has been verified in many studies and has reported antibacterial, anti-inflammatory, and anti-cancer effects.
Melitin has antibacterial, anti-inflammatory, and anti-cancer effects.
Melitin can kill pathogens such as bacteria and viruses.
It is suggested that it may be effective against resistant bacteria and the new coronavirus.
The anti-inflammatory properties of melitin inhibit inflammation by activating the cells of the immune system and reducing the production of inflammatory substances. For chronic inflammatory diseases such as rheumatoid arthritis and Heberden's nodular neuropathy, bee acupuncture therapy has a long history and has been proven to be effective.
Melitin, which has anti-cancer properties, is more toxic to cancer cells than normal cells. Melitin, in particular, punctures the cell membrane of cancer cells. This prevents the proliferation and metastasis of cancer cells by inducing cell death and inhibiting the expression of oncogenes. It has also been reported to be effective against various types of cancer, such as breast cancer and liver cancer. There are two types: stopping the growth of cancer cells and preventing cancer cells from metastasizing.
It is suggested that it may be effective against resistant bacteria and the new coronavirus.
The anti-inflammatory properties of melitin inhibit inflammation by activating the cells of the immune system and reducing the production of inflammatory substances. For chronic inflammatory diseases such as rheumatoid arthritis and Heberden's nodular neuropathy, bee acupuncture therapy has a long history and has been proven to be effective.
Melitin, which has anti-cancer properties, is more toxic to cancer cells than normal cells. Melitin, in particular, punctures the cell membrane of cancer cells. This prevents the proliferation and metastasis of cancer cells by inducing cell death and inhibiting the expression of oncogenes. It has also been reported to be effective against various types of cancer, such as breast cancer and liver cancer. There are two types: stopping the growth of cancer cells and preventing cancer cells from metastasizing.
How to use bee venom
There are two ways to use bee venom for treatment: bee stinger therapy and bee venom preparations.
Bee stinger therapy is a method of injecting venom into the body by pricking the bee's butt stinger directly. The location, frequency, and frequency of bites vary depending on the symptoms and constitution. Bee stinger therapy has not been approved for humans in Japan, but many papers have been submitted and there are many clinical effects.
Bee venom preparations are venom extracted from bee venom and processed into injections, tablets, creams, etc. It is said to be safer than bee stinger therapy, and it can be self-administered. Bee venom preparations are not common in Japan, but many products are sold overseas.
It has been found that bee venom has amazing effects, but bee venom contains ingredients that cause allergies, especially bee stinger therapy, which can cause severe anaphylactic shock, so people with allergies and those who are doing it for the first time should be very careful.
Bee venom has powerful physiological activity, but the interaction can enhance side effects, especially when used with steroids, antibiotics, etc. That is why it should be avoided with other drugs or consulted with a doctor. Quality control is important, and bee venom is a natural product, and its composition and concentration vary depending on the location, time, and method of collection. In addition, bee venom preparations sold overseas may have different quality control and safety standards than those in Japan. That's why it's important to choose a reliable facility or product.
A team from the Harley Perkins Institute of Medical Research in Australia has announced the results of a study that the molecules contained in such bee venom "inhibit the growth of breast cancer cells".
It has been reported that bee venom may be useful in the treatment of "atopic dermatitis", and in fact, bee stinger therapy, a folk medicine called "apitherapy", is said to be effective for inflammation, pain, and skin diseases of the body by being stung by bee stings.
The research team focused on a molecule called melitin contained in bee venom. Melitin is the main component of bee venom and is also the cause of pain when stung by bees, but bees not only use melitin as venom, but also use it as an antibacterial agent to repel pathogens infected by themselves.
So the research team experimented with how bee venom works on breast cancer cells cultured in the laboratory. Breast cancer can be classified into five types by pathological examination, but the breast cancer cells used in this experiment are several types, including triple-negative breast cancer.
There are only a limited number of effective treatments for triple-negative breast cancer, which accounts for 10~15% of breast cancers, and it is also known for its poor prognosis due to its high proliferation ability.
The team exposed bee venom collected from Ireland, the United Kingdom, and Australia to breast cancer cells and normal cells. As a result, bumblebee venom without melitin had little effect on breast cancer cells, while bee venom completely destroyed breast cancer cells and had the effect of inhibiting their growth. When melitin was blocked using antibodies, breast cancer cells exposed to bee venom survived, and it was also confirmed that this result was caused by melittin.
Ciara Duffy of the Harley Perkins Institute of Medicine commented, "The bee venom was very powerful, and we found that melitin can completely destroy cancer cell membranes within 60 minutes."
In addition, melitin has been found to interfere with the signaling necessary for cancer cell growth and inhibit the ability of cancer cells to replicate within just 20 minutes.
Ciara Duffy said, "Melitin is overexpressed in triple-negative breast cancer and is involved in the growth of cancer cells at the epidermal growth factor receptor(ＥＧＦＲ)It regulates signal transduction by inhibiting the activation of . We also found that it inhibits the activation of HER2, which is produced in excess in breast cancer cells."
On the other hand, it seems that exposing normal cells that produce EGFR and HER2 to melitin had almost no effect.
Since EGFR and HER2 overexpression can also be seen in other types of cancer, such as lung cancer, melitin may also target cancer cells other than breast cancer. In addition, in an experiment in which the research team compared the effects of artificially synthesized melitin with bee venom, it was found that most of the effects of bee venom can be obtained even with synthesized melitin.
Next, the research team administered a combination of melitin and chemotherapy agents such as docetaxel to mice with "breast cancer", and found that the combination of the two can effectively inhibit the growth of aggressive cancer tumors. This is believed to be due to the fact that melitin formed holes in breast cancer cells, and the introduction of therapeutic drugs from them promoted cell death.
Bee stinger therapy is a method of injecting venom into the body by pricking the bee's butt stinger directly. The location, frequency, and frequency of bites vary depending on the symptoms and constitution. Bee stinger therapy has not been approved for humans in Japan, but many papers have been submitted and there are many clinical effects.
Bee venom preparations are venom extracted from bee venom and processed into injections, tablets, creams, etc. It is said to be safer than bee stinger therapy, and it can be self-administered. Bee venom preparations are not common in Japan, but many products are sold overseas.
It has been found that bee venom has amazing effects, but bee venom contains ingredients that cause allergies, especially bee stinger therapy, which can cause severe anaphylactic shock, so people with allergies and those who are doing it for the first time should be very careful.
Bee venom has powerful physiological activity, but the interaction can enhance side effects, especially when used with steroids, antibiotics, etc. That is why it should be avoided with other drugs or consulted with a doctor. Quality control is important, and bee venom is a natural product, and its composition and concentration vary depending on the location, time, and method of collection. In addition, bee venom preparations sold overseas may have different quality control and safety standards than those in Japan. That's why it's important to choose a reliable facility or product.
A team from the Harley Perkins Institute of Medical Research in Australia has announced the results of a study that the molecules contained in such bee venom "inhibit the growth of breast cancer cells".
It has been reported that bee venom may be useful in the treatment of "atopic dermatitis", and in fact, bee stinger therapy, a folk medicine called "apitherapy", is said to be effective for inflammation, pain, and skin diseases of the body by being stung by bee stings.
The research team focused on a molecule called melitin contained in bee venom. Melitin is the main component of bee venom and is also the cause of pain when stung by bees, but bees not only use melitin as venom, but also use it as an antibacterial agent to repel pathogens infected by themselves.
So the research team experimented with how bee venom works on breast cancer cells cultured in the laboratory. Breast cancer can be classified into five types by pathological examination, but the breast cancer cells used in this experiment are several types, including triple-negative breast cancer.
There are only a limited number of effective treatments for triple-negative breast cancer, which accounts for 10~15% of breast cancers, and it is also known for its poor prognosis due to its high proliferation ability.
The team exposed bee venom collected from Ireland, the United Kingdom, and Australia to breast cancer cells and normal cells. As a result, bumblebee venom without melitin had little effect on breast cancer cells, while bee venom completely destroyed breast cancer cells and had the effect of inhibiting their growth. When melitin was blocked using antibodies, breast cancer cells exposed to bee venom survived, and it was also confirmed that this result was caused by melittin.
Ciara Duffy of the Harley Perkins Institute of Medicine commented, "The bee venom was very powerful, and we found that melitin can completely destroy cancer cell membranes within 60 minutes."
In addition, melitin has been found to interfere with the signaling necessary for cancer cell growth and inhibit the ability of cancer cells to replicate within just 20 minutes.
Ciara Duffy said, "Melitin is overexpressed in triple-negative breast cancer and is involved in the growth of cancer cells at the epidermal growth factor receptor(ＥＧＦＲ)It regulates signal transduction by inhibiting the activation of . We also found that it inhibits the activation of HER2, which is produced in excess in breast cancer cells."
On the other hand, it seems that exposing normal cells that produce EGFR and HER2 to melitin had almost no effect.
Since EGFR and HER2 overexpression can also be seen in other types of cancer, such as lung cancer, melitin may also target cancer cells other than breast cancer. In addition, in an experiment in which the research team compared the effects of artificially synthesized melitin with bee venom, it was found that most of the effects of bee venom can be obtained even with synthesized melitin.
Next, the research team administered a combination of melitin and chemotherapy agents such as docetaxel to mice with "breast cancer", and found that the combination of the two can effectively inhibit the growth of aggressive cancer tumors. This is believed to be due to the fact that melitin formed holes in breast cancer cells, and the introduction of therapeutic drugs from them promoted cell death.
Components of bee venom
１. Amines
Noradrenaline, Dopamine, Histamine, Serotonin
・Noradrenaline
It is a fluid transmitter of the sympathetic nervous system distributed throughout the body, and works in the brain with A-series 1~6 nerves, awakening, learning, urination, and blood circulation.
・Dopamine
It is an amino acid secreted in large quantities from the A-series nerves in the human brain, and the A10 nerve in particular has a special relationship with the frontal cortex, which is said to be the brain of creation, and requires a large amount of dopamine to activate mental emotions such as creativity, motivation, intelligence, memory, behavior, arousal, and pleasure. In addition, the A9 row nerve is also activated, so a lack of dopamine causes discomfort and leads to a decrease in motivation, behavior, memory, etc. In addition, Parkinson's disease and corticobasal ganglia degeneration(Designated Intractable Disease 7)It is an established theory that it is caused by a lack of dopamine. The bioactive amines of histamine, serotonin, and dopamine are common components of wasps and wasps other than Japan bees and Western bees.
・Histamine
It has a vasodilating effect, a contraction effect on smooth muscles such as the heart, a blood pressure lowering effect, and a degranulation effect of mast cells, which is the release of histamine, which is involved in the action of causing transient itching.
・Serotonin
It is a substance secreted by the B nerves lined up inside the A-series nerves in the brain and suppresses the overactivity of the A-series nerves. It is also contained in platelets, and when blood vessels are damaged, hemostatic substances are released from the platelets, but it also has the effect of causing pain.
・Noradrenaline
It is a fluid transmitter of the sympathetic nervous system distributed throughout the body, and works in the brain with A-series 1~6 nerves, awakening, learning, urination, and blood circulation.
・Dopamine
It is an amino acid secreted in large quantities from the A-series nerves in the human brain, and the A10 nerve in particular has a special relationship with the frontal cortex, which is said to be the brain of creation, and requires a large amount of dopamine to activate mental emotions such as creativity, motivation, intelligence, memory, behavior, arousal, and pleasure. In addition, the A9 row nerve is also activated, so a lack of dopamine causes discomfort and leads to a decrease in motivation, behavior, memory, etc. In addition, Parkinson's disease and corticobasal ganglia degeneration(Designated Intractable Disease 7)It is an established theory that it is caused by a lack of dopamine. The bioactive amines of histamine, serotonin, and dopamine are common components of wasps and wasps other than Japan bees and Western bees.
・Histamine
It has a vasodilating effect, a contraction effect on smooth muscles such as the heart, a blood pressure lowering effect, and a degranulation effect of mast cells, which is the release of histamine, which is involved in the action of causing transient itching.
・Serotonin
It is a substance secreted by the B nerves lined up inside the A-series nerves in the brain and suppresses the overactivity of the A-series nerves. It is also contained in platelets, and when blood vessels are damaged, hemostatic substances are released from the platelets, but it also has the effect of causing pain.
２. Peptides
Apamine МCD - Peptide Adrapine Melitin
・peptide
Both act on cell membranes.
Meltin has a strong sea surface active effect, so it plays an important role in controlling calcium ions.
・Apamine
It manifests a sedative and stimulant effect on the nerves.
・МCD-peptide
МCD-peptide acts on the membrane of mast cells and plays a leading role in degranulation to release histamine.
・Adravin
It has an analgesic effect.
・peptide
Both act on cell membranes.
Meltin has a strong sea surface active effect, so it plays an important role in controlling calcium ions.
・Apamine
It manifests a sedative and stimulant effect on the nerves.
・МCD-peptide
МCD-peptide acts on the membrane of mast cells and plays a leading role in degranulation to release histamine.
・Adravin
It has an analgesic effect.
３. Enzymes
Phospholipase A2 and hyalnonitase
・Phospholipase A2
It acts on cell membranes and is involved in the production of prostaglandins, which are painful substances.
・Hyalnonitase
It has the effect of breaking down connective tissue and penetrates bee venom components.
Phospholipase A2 and hyalnonitase can be allergens to humans on their own, but soaking them in honey has a great power to repel the body's viruses and bacteria and improve immunity.
・Phospholipase A2
It acts on cell membranes and is involved in the production of prostaglandins, which are painful substances.
・Hyalnonitase
It has the effect of breaking down connective tissue and penetrates bee venom components.
Phospholipase A2 and hyalnonitase can be allergens to humans on their own, but soaking them in honey has a great power to repel the body's viruses and bacteria and improve immunity.
４. Sugars
Glucose and Glatose
・Glucose
Glucose is circulating in the animal's blood as blood sugar. Sugar is produced by photosynthesis from water and carbon dioxide using energy from sunlight in chloroplasts contained in plants. Glucose is the most important source of energy for cellular respiration. In plants, it is stored as a starch, and in animals it is stored as a glycogen-like polymer.
Glucose is on the World Health Organization Model List of Essential Medicines.
・Glaktosis
It is found in dairy products, sugar beets, gum, and mucus, and is also synthesized in the human body to form glycolipids and glycoproteins in various tissues. It is a food that provides energy.
・Glucose
Glucose is circulating in the animal's blood as blood sugar. Sugar is produced by photosynthesis from water and carbon dioxide using energy from sunlight in chloroplasts contained in plants. Glucose is the most important source of energy for cellular respiration. In plants, it is stored as a starch, and in animals it is stored as a glycogen-like polymer.
Glucose is on the World Health Organization Model List of Essential Medicines.
・Glaktosis
It is found in dairy products, sugar beets, gum, and mucus, and is also synthesized in the human body to form glycolipids and glycoproteins in various tissues. It is a food that provides energy.
5. Polyamines
Ptresin spermidine spermin
2013In the same year, a review article in the scientific journal "Cell" published "Seven biological interventions (eating habits and substances) that are effective in anti-aging".
One of them contains a substance called spermidine, which is a type of polyamines. The ability to produce polyamines and their concentrations in organs and tissues decline with age after growth.
Polyamines are essential components for life that exist in various organisms, from viruses to human cells. Polyamine is a general term for hydrocarbons that have two or more amino groups in the molecule, and is mainly involved in cell regeneration, and it is said that "cell aging becomes significant due to lack of polyamines."
Polyamine is a component synthesized by the body by arginine and ornithine, which are a type of amino acid.
Polyamines have been found to have the effect of extending healthy life expectancy, and can be expected to prevent various diseases and diseases that increase the risk of occurrence with aging.
The discovery of a compound called polyamine is very old, and the first scientific description is that Dr. Levenhoek, who is famous as the founder of microbial research using a microscope, discovered it as a crystal in semen in 1678.
However, the compound name was decided about 250 years later, in the 1920s, when it was named spermin and its official structure was determined. Since the 1950s, biochemical and physiological research has been actively conducted as a polyamine, including spermidine and putresin.
Recently, "basic and applied research on the relationship between polyamines and healthy life expectancy" has been carried out mainly in Japan and Europe. From such new research, it is expected that "prevention of cardiovascular diseases, dementia, cancer, etc., including arteriosclerosis" caused by cell aging, which is the effect of "prolonging healthy life expectancy through the suppression of normal cells (maintenance of normal function)".
There are more than 20 types of polyamines in the human body, and the three most representative are spermin, spermidine, and putrescin.
Polyamines are collective terms such as "ptresin", "spermidine", and "spermin", and are substances that are contained in the cells of all species and are involved in cell life activities, including cell growth and proliferation. In other words, polyamines are "important substances that are indispensable for maintaining the normal state of cells and maintaining vital activities."
The ability to produce polyamines and their concentrations in organs and tissues decrease with age after the growth of living organisms.
In humans, polyamine biosynthesis and concentration in vivo gradually decrease around the age of 18~20 years. Since the decline in polyamine biosynthesis capacity is the starting point of aging, it can be said that cell function fails when the biosynthesis capacity and concentration of polyamine in vivo gradually decrease from the 20s to the 30s, 40s, and 50s, and the polyamine concentration decreases to a level where the normal cell cannot be maintained around the age of 60.
Various functional disorders occur in the body, and the risk of developing lifestyle-related diseases and geriatric diseases increases sharply.
30There are previous studies that measured blood polyamine levels for people aged 100 years and over. In this report, the concentration of polyamines in the blood of people in their 60s~80s was significantly lower than that of those in their 30s~50s, and that of people in their 90s~100s and older was higher than that of those in their 60s~80s, and was rather close to the concentration in their 30s~50s. I believe that this result suggests that polyamines are involved in longevity, and I speculate that people with high blood polyamine levels in their 60s~80s survive and live longer from their 90s to 100 years old.
In other words, if we can maintain high levels of polyamine concentrations in the organism, we can reduce the risk of diseases and diseases caused by aging (remain disease-free)
One of them contains a substance called spermidine, which is a type of polyamines. The ability to produce polyamines and their concentrations in organs and tissues decline with age after growth.
Polyamines are essential components for life that exist in various organisms, from viruses to human cells. Polyamine is a general term for hydrocarbons that have two or more amino groups in the molecule, and is mainly involved in cell regeneration, and it is said that "cell aging becomes significant due to lack of polyamines."
Polyamine is a component synthesized by the body by arginine and ornithine, which are a type of amino acid.
Polyamines have been found to have the effect of extending healthy life expectancy, and can be expected to prevent various diseases and diseases that increase the risk of occurrence with aging.
The discovery of a compound called polyamine is very old, and the first scientific description is that Dr. Levenhoek, who is famous as the founder of microbial research using a microscope, discovered it as a crystal in semen in 1678.
However, the compound name was decided about 250 years later, in the 1920s, when it was named spermin and its official structure was determined. Since the 1950s, biochemical and physiological research has been actively conducted as a polyamine, including spermidine and putresin.
Recently, "basic and applied research on the relationship between polyamines and healthy life expectancy" has been carried out mainly in Japan and Europe. From such new research, it is expected that "prevention of cardiovascular diseases, dementia, cancer, etc., including arteriosclerosis" caused by cell aging, which is the effect of "prolonging healthy life expectancy through the suppression of normal cells (maintenance of normal function)".
There are more than 20 types of polyamines in the human body, and the three most representative are spermin, spermidine, and putrescin.
Polyamines are collective terms such as "ptresin", "spermidine", and "spermin", and are substances that are contained in the cells of all species and are involved in cell life activities, including cell growth and proliferation. In other words, polyamines are "important substances that are indispensable for maintaining the normal state of cells and maintaining vital activities."
The ability to produce polyamines and their concentrations in organs and tissues decrease with age after the growth of living organisms.
In humans, polyamine biosynthesis and concentration in vivo gradually decrease around the age of 18~20 years. Since the decline in polyamine biosynthesis capacity is the starting point of aging, it can be said that cell function fails when the biosynthesis capacity and concentration of polyamine in vivo gradually decrease from the 20s to the 30s, 40s, and 50s, and the polyamine concentration decreases to a level where the normal cell cannot be maintained around the age of 60.
Various functional disorders occur in the body, and the risk of developing lifestyle-related diseases and geriatric diseases increases sharply.
30There are previous studies that measured blood polyamine levels for people aged 100 years and over. In this report, the concentration of polyamines in the blood of people in their 60s~80s was significantly lower than that of those in their 30s~50s, and that of people in their 90s~100s and older was higher than that of those in their 60s~80s, and was rather close to the concentration in their 30s~50s. I believe that this result suggests that polyamines are involved in longevity, and I speculate that people with high blood polyamine levels in their 60s~80s survive and live longer from their 90s to 100 years old.
In other words, if we can maintain high levels of polyamine concentrations in the organism, we can reduce the risk of diseases and diseases caused by aging (remain disease-free)
Polyamine deficiency due to aging can be eliminated!
Food intake is difficult.
How easy it is to drink bee-produced biosynthetics
Polyamines are produced in cells, but their biosynthetic ability decreases with age, so if the polyamine (endogenous polyamine) produced in your body decreases, you can replenish it by ingesting polyamine (exogenous polyamines) from outside the body.
Exogenous polyamines include dietary polyamines and polyamines produced by gut bacteria.
How easy it is to drink bee-produced biosynthetics
Polyamines are produced in cells, but their biosynthetic ability decreases with age, so if the polyamine (endogenous polyamine) produced in your body decreases, you can replenish it by ingesting polyamine (exogenous polyamines) from outside the body.
Exogenous polyamines include dietary polyamines and polyamines produced by gut bacteria.
１. Eating foods high in polyamines
Polyamines in food are absorbed in the small intestine and transported by the blood to cells throughout the body. Foods high in polyamines include soybeans, red beans, shiitake mushrooms, mushrooms, peppers, peas, green peas, corn, citrus fruits such as oranges, wheat germ, pistachios, blue cheese (trace amounts in processed cheese), turban shells, mussels (especially offal), cod duck, salmon fish, beef giblets (intestines), chicken liver, etc. If you are aware of these and incorporate them into your diet, you can increase your polyamine intake.
２. Eating foods that promote polyamine biosynthesis in gut bacteria
By eating a diet that contains ingredients that promote polyamine biosynthesis by gut bacteria, you can increase the concentration of polyamines in the gut and increase the supply to the body.
Since the species of bacteria that inhabit the intestine vary greatly from person to person, and in addition, the composition of our diet, which feeds on intestinal bacteria, also varies greatly from person to person, the concentration of polyamines in the intestinal lumen inevitably varies greatly from person to person, but it has been confirmed that the bacteria produce ptresin and spermidine.
For example, putresin, the most dominant polyamine in the human large intestine, has a concentration difference of about 1000 times between humans with high concentrations and low concentrations. Humans with high levels of ptrecin in the colon can replenish a lot of polyamines derived from intestinal bacteria, but humans with low concentrations show that it is almost impossible to replenish polyamines in the body with polyamines derived from intestinal bacteria.
Expectations for its effectiveness on honey synthetics are growing.
Since the species of bacteria that inhabit the intestine vary greatly from person to person, and in addition, the composition of our diet, which feeds on intestinal bacteria, also varies greatly from person to person, the concentration of polyamines in the intestinal lumen inevitably varies greatly from person to person, but it has been confirmed that the bacteria produce ptresin and spermidine.
For example, putresin, the most dominant polyamine in the human large intestine, has a concentration difference of about 1000 times between humans with high concentrations and low concentrations. Humans with high levels of ptrecin in the colon can replenish a lot of polyamines derived from intestinal bacteria, but humans with low concentrations show that it is almost impossible to replenish polyamines in the body with polyamines derived from intestinal bacteria.
Expectations for its effectiveness on honey synthetics are growing.
・Spermin
It is the first polyamine to be discovered and is deeply involved in cell metabolism and other factors.
・Spermidine
It has the effect of activating enzymes involved in cell regeneration.
・Putresin
It is a polyamine with the simplest structure and is said to be mostly broken down by enzymes in the intestines. Polyamines are components found in various organisms with cells and are found in fermented soybeans such as natto.
Polyamines
It is responsible for copying genes associated with cell division and is an essential component for cell regeneration. It is expected to have the effect of increasing metabolism and preventing aging.
It is the first polyamine to be discovered and is deeply involved in cell metabolism and other factors.
・Spermidine
It has the effect of activating enzymes involved in cell regeneration.
・Putresin
It is a polyamine with the simplest structure and is said to be mostly broken down by enzymes in the intestines. Polyamines are components found in various organisms with cells and are found in fermented soybeans such as natto.
Polyamines
It is responsible for copying genes associated with cell division and is an essential component for cell regeneration. It is expected to have the effect of increasing metabolism and preventing aging.
6. other
Phospholipids and amino acids
It is the main component of bee venom, but strangely, amines and enzymes are common to the human body and have important effects.
In particular, amines, which are brain neurotransmitters, have 1,000,000,000(billion)It is a substance that exhibits bioactive effects in an ultra-trace amount of 1 gram per minute.
Amino acid complex natural science that brings out the greatest effect with the smallest substance is condensed into a tiny bee stinger fluid that glows on the tip of a western bee's tiny needle.
This is where it is necessary to strictly refrain from overstimulation with bee stinger therapy.
Suddenly, these hormone-like substances injected from outside the body disrupt the orderly biological response, leading to disordered inflammatory and anaphylactic reactions.
Harmful substances, represented by the environmental hormone dioxin, affect in the amount of 1 drop in a 50-meter pool.
In particular, amines, which are brain neurotransmitters, have 1,000,000,000(billion)It is a substance that exhibits bioactive effects in an ultra-trace amount of 1 gram per minute.
Amino acid complex natural science that brings out the greatest effect with the smallest substance is condensed into a tiny bee stinger fluid that glows on the tip of a western bee's tiny needle.
This is where it is necessary to strictly refrain from overstimulation with bee stinger therapy.
Suddenly, these hormone-like substances injected from outside the body disrupt the orderly biological response, leading to disordered inflammatory and anaphylactic reactions.
Harmful substances, represented by the environmental hormone dioxin, affect in the amount of 1 drop in a 50-meter pool.
Medicinal of insect venom
If you are stung, it is poisonous, if you drink it, it is a miracle medicine
Waxes are considered very dangerous because they are relatively large, have strong venom, and are highly aggressive. The largest species, the giant wasp, has an average daily flight distance of over 100 km, and has power that is incomparable to other creatures, such as moving its wings at a high speed of more than 1,000 times per minute. In addition, symptoms such as very strong pain, inflammation, and increased body temperature occur when stung, and because it contains neurotoxin components, there are many cases where a large number of stings can paralyze, become breathless, and die.
However, on the other hand, it has been used for food and medicinal purposes since ancient times, and is said to be effective in bactericidal and detoxifying effects, blood clotting promotion, diuresis, analgesic and antispasmodic effects, and anti-inflammatory effects in Chinese medicine.
Adult wasps catch insects, but do not eat them themselves, but feed them to the larvae. Instead, they receive a nutrient solution secreted by the larvae in liquid form. This liquid contains plenty of amino acids, which are the basis of protein, and has been reported to have the effect of suppressing the rise in lactic acid levels, which is a guide to fatigue.
Another feature is the deadly poisonous ingredient. It is a highly poisonous ingredient that can kill you if you are stung, but it becomes harmless when it enters the mouth and is decomposed and absorbed by the gastrointestinal tract, turning it into a very effective ingredient. Therefore, honey synthetics soaked in honey are said to have effects on fatigue recovery, blood sugar control, lifestyle prevention, and measures against habitual diseases, insomnia, neuralgia, asthma, and skin beautification by licking an appropriate amount with a wooden teaspoon every morning and evening.
However, on the other hand, it has been used for food and medicinal purposes since ancient times, and is said to be effective in bactericidal and detoxifying effects, blood clotting promotion, diuresis, analgesic and antispasmodic effects, and anti-inflammatory effects in Chinese medicine.
Adult wasps catch insects, but do not eat them themselves, but feed them to the larvae. Instead, they receive a nutrient solution secreted by the larvae in liquid form. This liquid contains plenty of amino acids, which are the basis of protein, and has been reported to have the effect of suppressing the rise in lactic acid levels, which is a guide to fatigue.
Another feature is the deadly poisonous ingredient. It is a highly poisonous ingredient that can kill you if you are stung, but it becomes harmless when it enters the mouth and is decomposed and absorbed by the gastrointestinal tract, turning it into a very effective ingredient. Therefore, honey synthetics soaked in honey are said to have effects on fatigue recovery, blood sugar control, lifestyle prevention, and measures against habitual diseases, insomnia, neuralgia, asthma, and skin beautification by licking an appropriate amount with a wooden teaspoon every morning and evening.
Two poisons
There are two types of poisons: poison,
Poison is dangerous to eat because it is poisonous to the body. Venom only releases venom from its fangs and needles, so you just need to be careful.
The venomous snake called Yamakagashi is a docile snake with a beautiful pattern, but it has both poison and venom venom, so it is dangerous from the outside.
Palm crabs are also boiled and remain blue, and those that do not turn red are very dangerous as poison.
Scorpions are Venom, so they are also eaten as a snack locally.
Puffer fish are poison. You need a prefectural training and license to handle puffer fish, and it is a violation if you do not work while putting poisonous organs and organs in a case with a lock while cooking.
Honey synthesizers are poisoned from the needles of the buttocks because they are pickled alive, and they are harmless after death. The poison is soaked in honey for a long time and turns into a good medicinal substance.
Poison is dangerous to eat because it is poisonous to the body. Venom only releases venom from its fangs and needles, so you just need to be careful.
The venomous snake called Yamakagashi is a docile snake with a beautiful pattern, but it has both poison and venom venom, so it is dangerous from the outside.
Palm crabs are also boiled and remain blue, and those that do not turn red are very dangerous as poison.
Scorpions are Venom, so they are also eaten as a snack locally.
Puffer fish are poison. You need a prefectural training and license to handle puffer fish, and it is a violation if you do not work while putting poisonous organs and organs in a case with a lock while cooking.
Honey synthesizers are poisoned from the needles of the buttocks because they are pickled alive, and they are harmless after death. The poison is soaked in honey for a long time and turns into a good medicinal substance.
Language
